Small molecules that allosterically inhibit p21-activated kinase activity by binding to the regulatory p21-binding domain

p21-activated kinases (PAKs) are key regulators of actin dynamics, cell proliferation and cell survival. Deregulation of PAK activity contributes to the pathogenesis of various human diseases, including cancer and neurological disorders. Using an ELISA-based screening protocol, we identified naphtho...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Exp Mol Med
Prif Awduron: Kim, Duk-Joong, Choi, Chang-Ki, Lee, Chan-Soo, Park, Mee-Hee, Tian, Xizhe, Kim, Nam Doo, Lee, Kee-In, Choi, Joong-Kwon, Ahn, Jin Hee, Shin, Eun-Young, Shin, Injae, Kim, Eung-Gook
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2016
Pynciau:
Original Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4855275/
https://ncbi.nlm.nih.gov/pubmed/27126178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emm.2016.13
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