Sequential Dosing in Chemosensitization: Targeting the PI3K/Akt/mTOR Pathway in Neuroblastoma

Breaking resistance to chemotherapy is a major goal of combination therapy in many tumors, including advanced neuroblastoma. We recently demonstrated that increased activity of the PI3K/Akt network is associated with poor prognosis, thus providing an ideal target for chemosensitization. Here we show...

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Autores principales: Westhoff, Mike-Andrew, Faham, Najmeh, Marx, Daniela, Nonnenmacher, Lisa, Jennewein, Claudia, Enzenmüller, Stefanie, Gonzalez, Patrick, Fulda, Simone, Debatin, Klaus-Michael
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3877010/
https://ncbi.nlm.nih.gov/pubmed/24391739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0083128
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