Heritable Influence of DBH on Adrenergic and Renal Function: Twin and Disease Studies

BACKGROUND: Elevated sympathetic activity is associated with kidney dysfunction. Here we used twin pairs to probe heritability of GFR and its genetic covariance with other traits. METHODS: We evaluated renal and adrenergic phenotypes in twins. GFR was estimated by CKD-EPI algorithm. Heritability and...

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Hlavní autoři: Pasha, Dalal N., Davis, Jason T., Rao, Fangwen, Chen, Yuqing, Wen, Gen, Fung, Maple M., Mahata, Manjula, Zhang, Kuixing, Trzebinska, Danuta, Mustapic, Maja, Hightower, C. Makena, Lipkowitz, Michael S., Ji, Ming, Ziegler, Michael G., Nievergelt, Caroline M., O'Connor, Daniel T.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2013
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3876991/
https://ncbi.nlm.nih.gov/pubmed/24391727
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0082956
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