The catecholamine biosynthetic enzyme dopamine β-hydroxylase (DBH): first genome-wide search positions trait-determining variants acting additively in the proximal promoter

Dopamine beta-hydroxylase (DBH) is the biosynthetic enzyme catalyzing formation of norepinephrine. Changes in DBH expression or activity have been implicated in the pathogenesis of cardiovascular and neuropsychiatric disorders. Genetic determination of DBH enzymatic activity and its secretion are on...

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Bibliografiska uppgifter
I publikationen:Hum Mol Genet
Huvudupphovsmän: Mustapic, Maja, Maihofer, Adam X., Mahata, Manjula, Chen, Yuqing, Baker, Dewleen G., O'Connor, Daniel T., Nievergelt, Caroline M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2014
Ämnen:
Association Studies Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4222356/
https://ncbi.nlm.nih.gov/pubmed/24986918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddu332
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