The catecholamine biosynthetic enzyme dopamine β-hydroxylase (DBH): first genome-wide search positions trait-determining variants acting additively in the proximal promoter

Dopamine beta-hydroxylase (DBH) is the biosynthetic enzyme catalyzing formation of norepinephrine. Changes in DBH expression or activity have been implicated in the pathogenesis of cardiovascular and neuropsychiatric disorders. Genetic determination of DBH enzymatic activity and its secretion are on...

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Detalhes bibliográficos
Publicado no:Hum Mol Genet
Main Authors: Mustapic, Maja, Maihofer, Adam X., Mahata, Manjula, Chen, Yuqing, Baker, Dewleen G., O'Connor, Daniel T., Nievergelt, Caroline M.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
Assuntos:
Association Studies Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4222356/
https://ncbi.nlm.nih.gov/pubmed/24986918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddu332
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