NLRP3 Inflammasome Knockout Mice Are Protected against Ischemic but Not Cisplatin-Induced Acute Kidney Injury

We have demonstrated that caspase-1 is a mediator of both cisplatin-induced acute kidney injury (AKI) and ischemic AKI. As caspase-1 is activated in the inflammasome, we investigated the inflammasome in cisplatin-induced and ischemic AKI. Mice were injected with cisplatin or subjected to bilateral r...

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Detalhes bibliográficos
Main Authors: Kim, Hyun-Jung, Lee, Dong Won, Ravichandran, Kameswaran, O. Keys, Daniel, Akcay, Ali, Nguyen, Quocan, He, Zhibin, Jani, Alkesh, Ljubanovic, Danica, Edelstein, Charles L.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2013
Assuntos:
Gastrointestinal, Hepatic, Pulmonary, and Renal
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3876780/
https://ncbi.nlm.nih.gov/pubmed/23833276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.113.205732
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