Interleukin-18 binding protein transgenic mice are protected against ischemic acute kidney injury

IL-18 function is neutralized in IL-18 binding protein transgenic (IL-18BP Tg) mice. First, we determined whether IL-18BP Tg mice are protected against ischemic acute kidney injury (AKI). Ischemic AKI was induced by bilateral renal pedicle clamping. IL-18BP Tg mice were functionally and histological...

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Main Authors: He, Zhibin, Lu, Lawrence, Altmann, Christopher, Hoke, Thomas S., Ljubanovic, Danica, Jani, Alkesh, Dinarello, Charles A., Faubel, Sarah, Edelstein, Charles L.
Format: Artigo
Language:Inglês
Published: American Physiological Society 2008
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2584896/
https://ncbi.nlm.nih.gov/pubmed/18753296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.90288.2008
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