Protective Action of Anandamide and Its COX-2 Metabolite against l-Homocysteine-Induced NLRP3 Inflammasome Activation and Injury in Podocytes

Recent studies have demonstrated that l-homocysteine (Hcys)-induced podocyte injury leading to glomerular damage or sclerosis is attributable to the activation of the nucleotide-binding oligomerization domain–like receptor containing pyrin domain 3 (NLRP3) inflammasome. Given the demonstrated anti-i...

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Bibliographische Detailangaben
Veröffentlicht in:J Pharmacol Exp Ther
Hauptverfasser: Li, Guangbi, Xia, Min, Abais, Justine M., Boini, Krishna, Li, Pin-Lan, Ritter, Joseph K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Pharmacology and Experimental Therapeutics 2016
Schlagworte:
Gastrointestinal, Hepatic, Pulmonary, and Renal
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4931881/
https://ncbi.nlm.nih.gov/pubmed/27189966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.116.233239
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