Nod-like Receptor Protein 3 (NLRP3) Inflammasome Activation and Podocyte Injury via Thioredoxin-Interacting Protein (TXNIP) during Hyperhomocysteinemia

NADPH oxidase-derived reactive oxygen species (ROS) have been reported to activate NLRP3 inflammasomes resulting in podocyte and glomerular injury during hyperhomocysteinemia (hHcys). However, the mechanism by which the inflammasome senses ROS is still unknown in podocytes upon hHcys stimulation. Th...

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Detalhes bibliográficos
Main Authors: Abais, Justine M., Xia, Min, Li, Guangbi, Chen, Yang, Conley, Sabena M., Gehr, Todd W. B., Boini, Krishna M., Li, Pin-Lan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4175351/
https://ncbi.nlm.nih.gov/pubmed/25138219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.567537
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