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CONTRIBUTION OF GUANINE NUCLEOTIDE EXCHANGE FACTOR VAV2 TO NLRP3 INFLAMMASOME ACTIVATION IN MOUSE PODOCYTES DURING HYPERHOMOCYSTEINEMIA
NADPH oxidase (NOX)-derived reactive oxygen species (ROS) have been demonstrated to mediate the activation of NOD-like receptor protein 3 (NLRP3) inflammasomes in podocytes in response to elevated levels of homocysteine (Hcys). However, it remains unknown how NLRP3 inflammasome activation is trigger...
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| Publicado no: | Free Radic Biol Med |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5423457/ https://ncbi.nlm.nih.gov/pubmed/28193546 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2017.02.027 |
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