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Potent and long-lasting inhibition of human P2X2 receptors by copper

P2X receptors are ion channels gated by ATP. In rodents these channels are modulated by zinc and copper. Zinc is co-released with neurotransmitter at some synapses and can modulate neuronal activity, but the role of copper in the brain is unclear. Rat P2X2 receptors show potentiation by 2–100 µM zin...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Punthambaker, Sukanya, Hume, Richard I.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3876483/
https://ncbi.nlm.nih.gov/pubmed/24067922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2013.09.001
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