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Potent and long-lasting inhibition of human P2X2 receptors by copper

P2X receptors are ion channels gated by ATP. In rodents these channels are modulated by zinc and copper. Zinc is co-released with neurotransmitter at some synapses and can modulate neuronal activity, but the role of copper in the brain is unclear. Rat P2X2 receptors show potentiation by 2–100 µM zin...

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Detalhes bibliográficos
Main Authors: Punthambaker, Sukanya, Hume, Richard I.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3876483/
https://ncbi.nlm.nih.gov/pubmed/24067922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2013.09.001
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