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High Potency Zinc Modulation of Human P2X2 Receptors and Low Potency Zinc Modulation of Rat P2X2 Receptors Share a Common Molecular Mechanism

Human P2X2 receptors (hP2X2) are strongly inhibited by zinc over the range of 2–100 μm, whereas rat P2X2 receptors (rP2X2) are strongly potentiated over the same range, and then inhibited by zinc over 100 μm. However, the biological role of zinc modulation is unknown in either species. To identify c...

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Bibliografiske detaljer
Main Authors: Punthambaker, Sukanya, Blum, Jacob A., Hume, Richard I.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3381168/
https://ncbi.nlm.nih.gov/pubmed/22556417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.369157
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