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Cysteine Substitution Mutagenesis and the Effects of Methanethiosulfonate Reagents at P2X(2) and P2X(4) Receptors Support a Core Common Mode of ATP Action at P2X Receptors
The agonist binding site of ATP-gated P2X receptors is distinct from other ATP-binding proteins. Mutagenesis on P2X(1) receptors of conserved residues in mammalian P2X receptors has established the paradigm that three lysine residues, as well as FT and NFR motifs, play an important role in mediating...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2459275/ https://ncbi.nlm.nih.gov/pubmed/18487206 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M800294200 |
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