Analysis of off-target effects of CRISPR/Cas-derived RNA-guided endonucleases and nickases

RNA-guided endonucleases (RGENs), derived from the prokaryotic adaptive immune system known as CRISPR/Cas, enable targeted genome engineering in cells and organisms. RGENs are ribonucleoproteins that consist of guide RNA and Cas9, a protein component originated from Streptococcus pyogenes. These enz...

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Bibliografiska uppgifter
Huvudupphovsmän: Cho, Seung Woo, Kim, Sojung, Kim, Yongsub, Kweon, Jiyeon, Kim, Heon Seok, Bae, Sangsu, Kim, Jin-Soo
Materialtyp: Artigo
Språk:Inglês
Publicerad: Cold Spring Harbor Laboratory Press 2014
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Method
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3875854/
https://ncbi.nlm.nih.gov/pubmed/24253446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.162339.113
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