Frequent truncating mutations of STAG2 in bladder cancer

Here we report the discovery of truncating mutations of the gene encoding the cohesin subunit STAG2, which regulates sister chromatid cohesion and segregation, in 36% of papillary non-invasive urothelial carcinomas and 16% of invasive urothelial carcinomas of the bladder. Our studies suggest that ST...

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Detalhes bibliográficos
Main Authors: Solomon, David A., Kim, Jung-Sik, Bondaruk, Jolanta, Shariat, Shahrokh F., Wang, Zeng-Feng, Elkahloun, Abdel G., Ozawa, Tomoko, Gerard, Julia, Zhuang, DaZhong, Zhang, Shizhen, Navai, Neema, Siefker-Radtker, Arleen, Phillips, Joanna J., Robinson, Brian D., Rubin, Mark A., Volkmer, Björn, Hautmann, Richard, Küfer, Rainer, Hogendoorn, Pancras C. W., Netto, George, Theodorescu, Dan, James, C. David, Czerniak, Bogdan, Miettinen, Markku, Waldman, Todd
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3875130/
https://ncbi.nlm.nih.gov/pubmed/24121789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.2800
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