Mutational Inactivation of STAG2 Causes Aneuploidy in Human Cancer

Most cancer cells are characterized by aneuploidy, an abnormal number of chromosomes. We have identified a clue to the mechanistic origins of aneuploidy through integrative genomic analyses of human tumors. A diverse range of tumor types were found to harbor deletions or inactivating mutations of ST...

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Detalhes bibliográficos
Main Authors: Solomon, David A., Kim, Taeyeon, Diaz-Martinez, Laura A., Fair, Joshlean, Elkahloun, Abdel G., Harris, Brent T., Toretsky, Jeffrey A., Rosenberg, Steven A., Shukla, Neerav, Ladanyi, Marc, Samuels, Yardena, James, C. David, Yu, Hongtao, Kim, Jung-Sik, Waldman, Todd
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3374335/
https://ncbi.nlm.nih.gov/pubmed/21852505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1203619
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