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Runx2 and Bone Morphogenic Protein 2 Regulate the Expression of an Alternative Lef1 Transcript During Osteoblast Maturation

Lymphoid Enhancer Binding Factor (Lef) 1 is a transcriptional effector of the Wnt/Lrp5/β-catenin signaling cascade, which regulates osteoblast differentiation, bone density and skeletal strength. In this study, we describe the expression and function of an alternative Lef1 isoform in osseous cells....

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Hoeppner, Luke H., Secreto, Frank, Jensen, Eric D., Li, Xiaodong, Kahler, Rachel A., Westendorf, Jennifer J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3874810/
https://ncbi.nlm.nih.gov/pubmed/19650108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcp.21879
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