Histone Deacetylase 7 Associates With Runx2 and Represses Its Activity During Osteoblast Maturation in a Deacetylation-Independent Manner

HDAC7 associates with Runx2 and represses Runx2 transcriptional activity in a deacetylase-independent manner. HDAC7 suppression accelerates osteoblast maturation. Thus, HDAC7 is a novel Runx2 co-repressor that regulates osteoblast differentiation. INTRODUCTION: Runx2 is a key regulator of gene expre...

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Bibliografiska uppgifter
Huvudupphovsmän: Jensen, Eric D, Schroeder, Tania M, Bailey, Jaclyn, Gopalakrishnan, Rajaram, Westendorf, Jennifer J
Materialtyp: Artigo
Språk:Inglês
Publicerad: Amer Soc Bone & Mineral Res. 2008
Ämnen:
Original Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2669158/
https://ncbi.nlm.nih.gov/pubmed/17997710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1359/JBMR.071104
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