Calcium signaling via Orai1 is essential for induction of nuclear orphan receptor pathway to drive T(H)17 differentiation

Orai1 is the pore subunit of Ca(2+) release-activated Ca(2+) (CRAC) channels that stimulate downstream signaling pathways crucial for T cell activation. CRAC channels are an attractive therapeutic target for alleviation of autoimmune diseases. Using high throughput chemical library screening targeti...

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Bibliografiske detaljer
Main Authors: Kim, Kyun-Do, Srikanth, Sonal, Tan, Yossan-Var, Yee, Ma-Khin, Jew, Marcus, Damoiseaux, Robert, Jung, Michael E., Shimizu, Saki, An, Dong Sung, Ribalet, Bernard, Waschek, James A., Gwack, Yousang
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3874217/
https://ncbi.nlm.nih.gov/pubmed/24307733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1302586
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