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ORAI1 deficiency impairs activated T cell death and enhances T cell survival
ORAI1 is a pore subunit of Ca(2+) release-activated Ca(2+) (CRAC) channels that mediate T cell receptor stimulation-induced Ca(2+) entry. A point mutation in ORAI1 (ORAI1(R91W)) causes severe combined immunodeficiency in human patients that is recapitulated in Orai1(−/−) mice, emphasizing its import...
Gorde:
| Egile Nagusiak: | , , , , , |
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| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
2011
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3178683/ https://ncbi.nlm.nih.gov/pubmed/21873530 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1100847 |
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