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Handling the 3-methylcytosine lesion by six human DNA polymerases members of the B-, X- and Y-families

Alkylating agents often generate 3-methylcytosine (3meC) lesions that are efficiently repaired by AlkB homologues. If AlkB homologue proteins are not functional, or the number of 3meC lesions exceeds the cellular repair capacity, the damage will persist in the genome and become substrate of DNA poly...

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Detalhes bibliográficos
Main Authors: Furrer, Antonia, van Loon, Barbara
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3874200/
https://ncbi.nlm.nih.gov/pubmed/24097443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt889
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