Multiple knockout mouse models reveal lincRNAs are required for life and brain development

Many studies are uncovering functional roles for long noncoding RNAs (lncRNAs), yet few have been tested for in vivo relevance through genetic ablation in animal models. To investigate the functional relevance of lncRNAs in various physiological conditions, we have developed a collection of 18 lncRN...

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Detalhes bibliográficos
Main Authors: Sauvageau, Martin, Goff, Loyal A, Lodato, Simona, Bonev, Boyan, Groff, Abigail F, Gerhardinger, Chiara, Sanchez-Gomez, Diana B, Hacisuleyman, Ezgi, Li, Eric, Spence, Matthew, Liapis, Stephen C, Mallard, William, Morse, Michael, Swerdel, Mavis R, D’Ecclessis, Michael F, Moore, Jennifer C, Lai, Venus, Gong, Guochun, Yancopoulos, George D, Frendewey, David, Kellis, Manolis, Hart, Ronald P, Valenzuela, David M, Arlotta, Paola, Rinn, John L
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2013
Assuntos:
Developmental Biology and Stem Cells
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3874104/
https://ncbi.nlm.nih.gov/pubmed/24381249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.01749
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