Multiple knockout mouse models reveal lincRNAs are required for life and brain development

Many studies are uncovering functional roles for long noncoding RNAs (lncRNAs), yet few have been tested for in vivo relevance through genetic ablation in animal models. To investigate the functional relevance of lncRNAs in various physiological conditions, we have developed a collection of 18 lncRN...

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Główni autorzy: Sauvageau, Martin, Goff, Loyal A, Lodato, Simona, Bonev, Boyan, Groff, Abigail F, Gerhardinger, Chiara, Sanchez-Gomez, Diana B, Hacisuleyman, Ezgi, Li, Eric, Spence, Matthew, Liapis, Stephen C, Mallard, William, Morse, Michael, Swerdel, Mavis R, D’Ecclessis, Michael F, Moore, Jennifer C, Lai, Venus, Gong, Guochun, Yancopoulos, George D, Frendewey, David, Kellis, Manolis, Hart, Ronald P, Valenzuela, David M, Arlotta, Paola, Rinn, John L
Format: Artigo
Język:Inglês
Wydane: eLife Sciences Publications, Ltd 2013
Hasła przedmiotowe:
Developmental Biology and Stem Cells
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3874104/
https://ncbi.nlm.nih.gov/pubmed/24381249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.01749
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