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A Bayesian decision-theoretic sequential response-adaptive randomization design

We propose a class of phase II clinical trial designs with sequential stopping and adaptive treatment allocation to evaluate treatment efficacy. Our work is based on two-arm (control and experimental treatment) designs with binary endpoints. Our overall goal is to construct more efficient and ethica...

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Detalhes bibliográficos
Main Authors: Jiang, Fei, Lee, J. Jack, Müller, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3873748/
https://ncbi.nlm.nih.gov/pubmed/23315678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sim.5735
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