Co-delivery of antigen and IL-12 by Venezuelan equine encephalitis virus replicon particles enhances antigen-specific immune responses and antitumor effects

We recently demonstrated that Venezuelan equine encephalitis virus-based replicon particle (VRPs) encoding tumor antigens could break tolerance in the immunomodulatory environment of advanced cancer. We hypothesized that local injection of VRP-expressing interleukin-12 (IL-12) at the site of injecti...

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Autors principals: Osada, Takuya, Berglund, Peter, Morse, Michael A., Hubby, Bolyn, Lewis, Whitney, Niedzwiecki, Donna, Yang, Xiao Yi, Hobeika, Amy, Burnett, Bruce, Devi, Gayathri R., Clay, Timothy M., Smith, Jonathan, Kim Lyerly, H.
Format: Artigo
Idioma:Inglês
Publicat: Springer-Verlag 2012
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3873731/
https://ncbi.nlm.nih.gov/pubmed/22488274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00262-012-1248-y
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