Apelin-13 Inhibits Large-Conductance Ca(2+)-Activated K(+) Channels in Cerebral Artery Smooth Muscle Cells via a PI3-Kinase Dependent Mechanism

Apelin-13 causes vasoconstriction by acting directly on APJ receptors in vascular smooth muscle (VSM) cells; however, the ionic mechanisms underlying this action at the cellular level remain unclear. Large-conductance Ca(2+)-activated K(+) (BK(Ca)) channels in VSM cells are critical regulators of me...

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Bibliographic Details
Main Authors: Modgil, Amit, Guo, Lirong, O’Rourke, Stephen T., Sun, Chengwen
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3873301/
https://ncbi.nlm.nih.gov/pubmed/24386141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0083051
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