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Metabolite-initiated protein misfolding may trigger Alzheimer's disease
Anfinsen showed that a protein's fold is specified by its sequence. Although it is clear why mutant proteins form amyloid, it is harder to rationalize why a wild-type protein adopts a native conformation in most individuals, but it misfolds in a minority of others, in what should be a common ex...
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| Main Authors: | , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC387320/ https://ncbi.nlm.nih.gov/pubmed/15034169 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0400924101 |
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