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A single point mutation reveals gating of the human ClC-5 Cl(−)/H(+) antiporter
ClC-5 is a 2Cl(−)/1H(+) antiporter highly expressed in endosomes of proximal tubule cells. It is essential for endocytosis and mutations in ClC-5 cause Dent's disease, potentially leading to renal failure. However, the physiological role of ClC-5 is still unclear. One of the main issues is whet...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Blackwell Science Inc
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3872759/ https://ncbi.nlm.nih.gov/pubmed/24099800 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2013.260240 |
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