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Large transient capacitive currents in wild-type lysosomal Cl(−)/H(+) antiporter ClC-7 and residual transport activity in the proton glutamate mutant E312A
ClC-7 is a lysosomal 2 Cl(−)/1 H(+) antiporter of the CLC protein family, which comprises Cl(−) channels and other Cl(−)/H(+) antiporters. Mutations in ClC-7 and its associated β subunit Ostm1 lead to osteopetrosis and lysosomal storage disease in humans and mice. Previous studies on other mammalian...
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| Publicado no: | J Gen Physiol |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Rockefeller University Press
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7681918/ https://ncbi.nlm.nih.gov/pubmed/33211806 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.202012583 |
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