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Conversion of the 2 Cl(−)/1 H(+) antiporter ClC-5 in a NO(3)(−)/H(+) antiporter by a single point mutation

Several members of the CLC family are secondary active anion/proton exchangers, and not passive chloride channels. Among the exchangers, the endosomal ClC-5 protein that is mutated in Dent's disease shows an extreme outward rectification that precludes a precise determination of its transport s...

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Main Authors: Zifarelli, Giovanni, Pusch, Michael
格式: Artigo
語言:Inglês
出版: Nature Publishing Group 2009
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2637338/
https://ncbi.nlm.nih.gov/pubmed/19131966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2008.284
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