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Lipid-Anchored SNAREs Lacking Transmembrane Regions Fully Support Membrane Fusion During Neurotransmitter Release

Synaptic vesicle fusion during neurotransmitter release is mediated by assembly of SNARE- and SM-protein complexes composed of syntaxin-1, SNAP-25, synaptobrevin-2/VAMP2, and Munc18-1. Current models suggest that SNARE-complex assembly catalyzes membrane fusion by pulling the transmembrane regions (...

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Hlavní autoři: Zhou, Peng, Bacaj, Taulant, Yang, Xiaofei, Pang, Zhiping P., Südhof, Thomas C.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3872166/
https://ncbi.nlm.nih.gov/pubmed/24120845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2013.09.010
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