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ROS Detoxification and Proinflammatory Cytokines Are Linked by p38 MAPK Signaling in a Model of Mature Astrocyte Activation

Astrocytes are the most abundant glial cell in the retinal nerve fiber layer (NFL) and optic nerve head (ONH), and perform essential roles in maintaining retinal ganglion cell (RGC) detoxification and homeostasis. Mature astrocytes are relatively quiescent, but rapidly undergo a phenotypic switch in...

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Autori principali: Nahirnyj, Adrian, Livne-Bar, Izhar, Guo, Xiaoxin, Sivak, Jeremy M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3871647/
https://ncbi.nlm.nih.gov/pubmed/24376630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0083049
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