MMP Mediated Degradation of Type IV Collagen Alpha 1 and Alpha 3 Chains Reflects Basement Membrane Remodeling in Experimental and Clinical Fibrosis – Validation of Two Novel Biomarker Assays

OBJECTIVES: Fibrosis is characterized by excessive tissue remodeling resulting from altered expression of various growth factors, cytokines and proteases. We hypothesized that matrix metalloproteinase (MMP) mediated degradation of type IV collagen, a main component of the basement membrane, will rel...

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Main Authors: Sand, Jannie Marie, Larsen, Lise, Hogaboam, Cory, Martinez, Fernando, Han, MeiLan, Røssel Larsen, Martin, Nawrocki, Arkadiusz, Zheng, Qinlong, Asser Karsdal, Morten, Leeming, Diana Julie
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3871599/
https://ncbi.nlm.nih.gov/pubmed/24376856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0084934
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