MMP Mediated Degradation of Type VI Collagen Is Highly Associated with Liver Fibrosis – Identification and Validation of a Novel Biochemical Marker Assay

BACKGROUND AND AIMS: During fibrogenesis, in which excessive remodeling of the extracellular matrix occurs, both the quantity of type VI collagen and levels of matrix metalloproteinases, including MMP-2 and MMP-9, increase significantly. Proteolytic degradation of type VI collagen into small fragmen...

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Detalhes bibliográficos
Main Authors: Veidal, Sanne Skovgård, Karsdal, Morten Asser, Vassiliadis, Efstathios, Nawrocki, Arkadiusz, Larsen, Martin Røssel, Nguyen, Quoc Hai Trieu, Hägglund, Per, Luo, Yunyun, Zheng, Qinlong, Vainer, Ben, Leeming, Diana Julie
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3173456/
https://ncbi.nlm.nih.gov/pubmed/21935455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0024753
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