Desnutrin/ATGL Activates PPARδ to Promote Mitochondrial Function for Insulin Secretion in Islet β cells

Excessive caloric intake leading to obesity is associated with insulin resistance and dysfuntion of islet β cells. High fat feeding decreases desnutrin (also called ATGL/PNPLA2) levels in islets. Here we show that desnutrin ablation via RIP-Cre (βKO) or RIP-CreER results in hyperglycemia with impair...

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Main Authors: Tang, Tianyi, Abbott, Marcia J., Ahmadian, Maryam, Lopes, Andressa B., Wang, Yuhui, Sul, Hei Sook
Formato: Artigo
Idioma:Inglês
Publicado: 2013
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3871209/
https://ncbi.nlm.nih.gov/pubmed/24268737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2013.10.012
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