Characterization of desnutrin functional domains: critical residues for triacylglycerol hydrolysis in cultured cells

Murine desnutrin/human ATGL is a triacylglycerol (TAG) hydrolase with a predicted catalytic dyad within an α-β hydrolase fold in the N-terminal region. In humans, mutations resulting in C-terminal truncation cause neutral lipid storage disease with myopathy. To identify critical functional domains,...

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Bibliografiske detaljer
Main Authors: Duncan, Robin E., Wang, Yuhui, Ahmadian, Maryam, Lu, Jennifer, Sarkadi-Nagy, Eszter, Sul, Hei Sook
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Biochemistry and Molecular Biology 2010
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2803232/
https://ncbi.nlm.nih.gov/pubmed/19692632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M000729
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