Desnutrin/ATGL Activates PPARδ to Promote Mitochondrial Function for Insulin Secretion in Islet β cells

Excessive caloric intake leading to obesity is associated with insulin resistance and dysfuntion of islet β cells. High fat feeding decreases desnutrin (also called ATGL/PNPLA2) levels in islets. Here we show that desnutrin ablation via RIP-Cre (βKO) or RIP-CreER results in hyperglycemia with impair...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Tang, Tianyi, Abbott, Marcia J., Ahmadian, Maryam, Lopes, Andressa B., Wang, Yuhui, Sul, Hei Sook
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3871209/
https://ncbi.nlm.nih.gov/pubmed/24268737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2013.10.012
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky