The cancer gene WWOX behaves as an inhibitor of SMAD3 transcriptional activity via direct binding

BACKGROUND: The WW domain containing protein WWOX has been postulated to behave as a tumor suppressor in breast and other cancers. Expression of this protein is lost in over 70% of ER negative tumors. This prompted us to investigate the phenotypic and gene expression effects of loss of WWOX expressi...

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Detalles Bibliográficos
Main Authors: Ferguson, Brent W, Gao, Xinsheng, Zelazowski, Maciej J, Lee, Jaeho, Jeter, Collene R, Abba, Martin C, Aldaz, C Marcelo
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2013
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3871008/
https://ncbi.nlm.nih.gov/pubmed/24330518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-13-593
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