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Deconstructing complexin function in activating and clamping Ca(2+)-triggered exocytosis by comparing knockout and knockdown phenotypes

Complexin, a presynaptic protein that avidly binds to assembled SNARE complexes, is widely acknowledged to activate Ca(2+)-triggered exocytosis. In addition, studies of invertebrate complexin mutants and of mouse neurons with a double knockdown (DKD) of complexin-1 and -2 suggested that complexin ma...

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מידע ביבליוגרפי
Main Authors: Yang, Xiaofei, Cao, Peng, Südhof, Thomas C.
פורמט: Artigo
שפה:Inglês
יצא לאור: National Academy of Sciences 2013
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3870694/
https://ncbi.nlm.nih.gov/pubmed/24297916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1321367110
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