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Mechanistic characterization and crystal structure of a small molecule inactivator bound to plasminogen activator inhibitor-1

Plasminogen activator inhibitor type-1 (PAI-1) is a member of the serine protease inhibitor (serpin) family. Excessive PAI-1 activity is associated with human disease, making it an attractive pharmaceutical target. However, like other serpins, PAI-1 has a labile structure, making it a difficult targ...

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Bibliografiske detaljer
Main Authors: Li, Shih-Hon, Reinke, Ashley A., Sanders, Karen L., Emal, Cory D., Whisstock, James C., Stuckey, Jeanne A., Lawrence, Daniel A.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3870673/
https://ncbi.nlm.nih.gov/pubmed/24297881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1216499110
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