Dual-reporter high-throughput screen for small-molecule in vivo inhibitors of plasminogen activator inhibitor type-1 yields a clinical lead candidate

Plasminogen activator inhibitor type-1 (PAI-1) is a serine protease inhibitor (serpin) implicated in numerous pathological processes, including coronary heart disease, arterial and venous thrombosis, and chronic fibrotic diseases. These associations have made PAI-1 an attractive pharmaceutical targe...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Reinke, Ashley A., Li, Shih-Hon, Warnock, Mark, Shaydakov, Maxim E., Guntaka, Naga Sandhya, Su, Enming J., Diaz, Jose A., Emal, Cory D., Lawrence, Daniel A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6364767/
https://ncbi.nlm.nih.gov/pubmed/30510136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.004885
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