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Mechanistic characterization and crystal structure of a small molecule inactivator bound to plasminogen activator inhibitor-1
Plasminogen activator inhibitor type-1 (PAI-1) is a member of the serine protease inhibitor (serpin) family. Excessive PAI-1 activity is associated with human disease, making it an attractive pharmaceutical target. However, like other serpins, PAI-1 has a labile structure, making it a difficult targ...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3870673/ https://ncbi.nlm.nih.gov/pubmed/24297881 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1216499110 |
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