Chk1 targeting reactivates PP2A tumor suppressor activity in cancer cells

Checkpoint kinase Chk1 is constitutively active in many cancer cell types and new generation Chk1 inhibitors show marked antitumor activity as single agents. Here we present a hitherto unrecognized mechanism that contributes to the response of cancer cells to Chk1 targeted therapy. Inhibiting chroni...

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Bibliografische gegevens
Hoofdauteurs: Khanna, Anchit, Kauko, Otto, Böckelman, Camilla, Laine, Anni, Schreck, Ilona, Partanen, Johanna I., Szwajda, Agnieszka, Bormann, Stefanie, Bilgen, Turker, Helenius, Merja, Pokharel, Yuba R., Pimanda, John, Russel, Mike R., Haglund, Caj, Cole, Kristina A., Klefström, Juha, Aittokallio, Tero, Weiss, Carsten, Ristimäki, Ari, Visakorpi, Tapio, Westermarck, Jukka
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2013
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3870284/
https://ncbi.nlm.nih.gov/pubmed/24072747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-13-1002
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