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Ebf1 and c-Myb repress Rag transcription downstream of Stat5 during early B cell development

The temporal control of recombination-activating gene (Rag) expression in developing lymphocytes prevents DNA breaks during periods of proliferation that could threaten genomic integrity. In developing B cells, the interleukin-7 receptor (IL-7R) and precursor B cell antigen receptor (pre-BCR) synerg...

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Detalhes bibliográficos
Main Authors: Timblin, Greg A, Schlissel, Mark S
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3870187/
https://ncbi.nlm.nih.gov/pubmed/24068669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1301675
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