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Dual Mechanism of Rag Gene Repression by c-Myb during Pre-B Cell Proliferation
Developing B lymphocytes undergo clonal expansion following successful immunoglobulin heavy chain gene rearrangement. During this proliferative burst, expression of the Rag genes is transiently repressed to prevent the generation of double-stranded DNA (dsDNA) breaks in cycling large pre-B cells. Th...
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| Publicado no: | Mol Cell Biol |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5452720/ https://ncbi.nlm.nih.gov/pubmed/28373291 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00437-16 |
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