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Rotor Termination Is Critically Dependent on Kinetic Properties of I (Kur) Inhibitors in an In Silico Model of Chronic Atrial Fibrillation

Inhibition of the atrial ultra-rapid delayed rectifier potassium current (I (Kur)) represents a promising therapeutic strategy in the therapy of atrial fibrillation. However, experimental and clinical data on the antiarrhythmic efficacy remain controversial. We tested the hypothesis that antiarrhyth...

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Detalhes bibliográficos
Main Authors: Scholz, Eberhard P., Carrillo-Bustamante, Paola, Fischer, Fathima, Wilhelms, Mathias, Zitron, Edgar, Dössel, Olaf, Katus, Hugo A., Seemann, Gunnar
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3869770/
https://ncbi.nlm.nih.gov/pubmed/24376659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0083179
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