Parameter Estimation of Ion Current Formulations Requires Hybrid Optimization Approach to Be Both Accurate and Reliable

Computational models of cardiac electrophysiology provided insights into arrhythmogenesis and paved the way toward tailored therapies in the last years. To fully leverage in silico models in future research, these models need to be adapted to reflect pathologies, genetic alterations, or pharmacologi...

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Detalhes bibliográficos
Publicado no:Front Bioeng Biotechnol
Main Authors: Loewe, Axel, Wilhelms, Mathias, Schmid, Jochen, Krause, Mathias J., Fischer, Fathima, Thomas, Dierk, Scholz, Eberhard P., Dössel, Olaf, Seemann, Gunnar
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2016
Assuntos:
Bioengineering and Biotechnology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4710757/
https://ncbi.nlm.nih.gov/pubmed/26793704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fbioe.2015.00209
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