Parameter Estimation of Ion Current Formulations Requires Hybrid Optimization Approach to Be Both Accurate and Reliable

Computational models of cardiac electrophysiology provided insights into arrhythmogenesis and paved the way toward tailored therapies in the last years. To fully leverage in silico models in future research, these models need to be adapted to reflect pathologies, genetic alterations, or pharmacologi...

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Dettagli Bibliografici
Pubblicato in:Front Bioeng Biotechnol
Autori principali: Loewe, Axel, Wilhelms, Mathias, Schmid, Jochen, Krause, Mathias J., Fischer, Fathima, Thomas, Dierk, Scholz, Eberhard P., Dössel, Olaf, Seemann, Gunnar
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2016
Soggetti:
Bioengineering and Biotechnology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4710757/
https://ncbi.nlm.nih.gov/pubmed/26793704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fbioe.2015.00209
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