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Parameter Estimation of Ion Current Formulations Requires Hybrid Optimization Approach to Be Both Accurate and Reliable

Computational models of cardiac electrophysiology provided insights into arrhythmogenesis and paved the way toward tailored therapies in the last years. To fully leverage in silico models in future research, these models need to be adapted to reflect pathologies, genetic alterations, or pharmacologi...

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Publicat a:Front Bioeng Biotechnol
Autors principals: Loewe, Axel, Wilhelms, Mathias, Schmid, Jochen, Krause, Mathias J., Fischer, Fathima, Thomas, Dierk, Scholz, Eberhard P., Dössel, Olaf, Seemann, Gunnar
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4710757/
https://ncbi.nlm.nih.gov/pubmed/26793704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fbioe.2015.00209
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