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In Silico Assessment of Efficacy and Safety of I(Kur) Inhibitors in Chronic Atrial Fibrillation: Role of Kinetics and State-Dependence of Drug Binding
Current pharmacological therapy against atrial fibrillation (AF), the most common cardiac arrhythmia, is limited by moderate efficacy and adverse side effects including ventricular proarrhythmia and organ toxicity. One way to circumvent the former is to target ion channels that are predominantly exp...
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| Publié dans: | Front Pharmacol |
|---|---|
| Auteurs principaux: | , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Frontiers Media S.A.
2017
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5681918/ https://ncbi.nlm.nih.gov/pubmed/29163179 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2017.00799 |
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