Histone Deacetylase Inhibition Rescues Gene Knockout Levels Achieved with Integrase-Defective Lentiviral Vectors Encoding Zinc-Finger Nucleases

Zinc-finger nucleases (ZFNs) work as dimers to induce double-stranded DNA breaks (DSBs) at predefined chromosomal positions. In doing so, they constitute powerful triggers to edit and to interrogate the function of genomic sequences in higher eukaryotes. A preferred route to introduce ZFNs into soma...

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Detalhes bibliográficos
Main Authors: Pelascini, Laetitia P.L., Maggio, Ignazio, Liu, Jin, Holkers, Maarten, Cathomen, Toni, Gonçalves, Manuel A.F.V.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2013
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3869538/
https://ncbi.nlm.nih.gov/pubmed/24059449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hgtb.2013.107
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