Trientine Reduces BACE1 Activity and Mitigates Amyloidosis via the AGE/RAGE/NF-κB Pathway in a Transgenic Mouse Model of Alzheimer's Disease

Aims: There is mounting evidence that the transition metal copper may play an important role in the pathophysiology of Alzheimer's disease (AD). Triethylene tetramine dihydrochloride (trientine), a CuII-selective chelator, is a commonly used treatment for Wilson's disease to decrease accum...

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Detalhes bibliográficos
Main Authors: Wang, Chun-Yan, Xie, Jing-Wei, Xu, Ye, Wang, Tao, Cai, Jian-Hui, Wang, Xu, Zhao, Bao-Lu, An, Li, Wang, Zhan-You
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2013
Assuntos:
Original Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3869419/
https://ncbi.nlm.nih.gov/pubmed/23541064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2012.5158
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