Hypoxia‐Triggered m‐Calpain Activation Evokes Endoplasmic Reticulum Stress and Neuropathogenesis in a Transgenic Mouse Model of Alzheimer's Disease

BACKGROUND: Previous studies have demonstrated that endoplasmic reticulum (ER) stress is activated in Alzheimer's disease (AD) brains. ER stress–triggered unfolded protein response (UPR) leads to tau phosphorylation and neuronal death. AIMS: In this study, we tested the hypothesis that hypoxia‐...

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Detaylı Bibliyografya
Yayımlandı:CNS Neurosci Ther
Asıl Yazarlar: Wang, Chun‐Yan, Xie, Jing‐Wei, Wang, Tao, Xu, Ye, Cai, Jian‐Hui, Wang, Xu, Zhao, Bao‐Lu, An, Li, Wang, Zhan‐You
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: John Wiley and Sons Inc. 2013
Konular:
Original Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6493504/
https://ncbi.nlm.nih.gov/pubmed/23889979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cns.12151
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